YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Summary
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Known Variants5 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs6031847 | 20:43,514,203 | C/T | regulatory region variant | — |
| rs7265519 | 20:43,515,270 | C/T | intron variant | — |
| rs2284265 | 20:43,517,041 | C/T | regulatory region variant | — |
| rs2267850 | 20:43,524,963 | C/T | regulatory region variant | — |
| rs184384561 | 20:43,530,482 | G/A | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.