ZBTB25
zinc finger and BTB domain containing 25
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants32 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs3742608 | 14:64,937,033 | G/C | intron variant | — |
| rs73265641 | 14:64,949,864 | G/A | 3 prime UTR variant | — |
| rs11626222 | 14:64,953,259 | G/A | 3 prime UTR variant | — |
| rs77637496 | 14:64,953,788 | T/C | — | benign |
| rs753539007 | 14:64,953,934 | A/G | — | uncertain significance |
| rs749840872 | 14:64,953,954 | G/T | — | uncertain significance |
| rs753284975 | 14:64,953,976 | C/G | — | uncertain significance |
| rs775261229 | 14:64,954,008 | C/T | — | uncertain significance |
| rs760763175 | 14:64,954,009 | G/A | — | uncertain significance |
| rs753129203 | 14:64,954,065 | C/T | — | likely benign |
| rs374600794 | 14:64,954,068 | C/T | — | uncertain significance |
| rs2550516049 | 14:64,954,098 | G/C | — | uncertain significance |
| rs199543825 | 14:64,954,147 | C/T | — | uncertain significance |
| rs61743629 | 14:64,954,187 | C/T | — | likely benign |
| rs561048684 | 14:64,954,232 | T/G | — | uncertain significance |
| rs2550516270 | 14:64,954,328 | T/A | — | uncertain significance |
| rs1450058627 | 14:64,954,335 | T/A | — | uncertain significance |
| rs2550516297 | 14:64,954,345 | A/C | — | uncertain significance |
| rs370011989 | 14:64,954,374 | G/A | — | uncertain significance |
| rs142592421 | 14:64,954,420 | C/T | — | benign |
| rs145365297 | 14:64,954,429 | T/C | — | uncertain significance |
| rs1135515 | 14:64,954,455 | T/C | — | uncertain significance |
| rs760872937 | 14:64,954,668 | C/T | — | uncertain significance |
| rs61742301 | 14:64,954,683 | A/G | — | benign |
| rs147617886 | 14:64,954,703 | C/T | — | likely benign |
| rs143894644 | 14:64,954,709 | C/T | — | uncertain significance |
| rs772559171 | 14:64,954,714 | T/C | — | uncertain significance |
| rs61985668 | 14:64,956,346 | T/C | intron variant | — |
| rs202160312 | 14:64,957,164 | T/C | — | uncertain significance |
| rs2550517682 | 14:64,957,176 | A/G | — | uncertain significance |
| rs140662536 | 14:64,957,224 | G/A | missense variant | — |
| rs376952271 | 14:64,957,241 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.