ZKSCAN3

zinc finger with KRAB and SCAN domains 3

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of autophagy; negative regulation of cellular senescence; and regulation of DNA-templated transcription. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants26 total

rsidPosition (GRCh37)AllelesClassClinVar
rs1449314766:28,326,535C/Aupstream gene variant
rs5751608986:28,327,460G/Tuncertain significance
rs7778120076:28,327,530A/Guncertain significance
rs14494576206:28,327,599T/Guncertain significance
rs24807397056:28,327,608A/Guncertain significance
rs14224062526:28,327,703G/Tuncertain significance
rs7665838216:28,329,147C/Tuncertain significance
rs7530158296:28,331,136G/Auncertain significance
rs3733404526:28,331,500C/Tuncertain significance
rs1998150626:28,331,539G/Tlikely benign
rs132140236:28,332,141G/Aintron variant
rs7620301776:28,333,235C/Tuncertain significance
rs7608133966:28,333,328G/Auncertain significance
rs7559271456:28,333,416C/Tuncertain significance
rs3724422686:28,333,440A/Guncertain significance
rs7730191636:28,333,467C/Tuncertain significance
rs3763117146:28,333,483G/Tuncertain significance
rs5714900286:28,333,497T/Cuncertain significance
rs5372109276:28,333,499A/Cuncertain significance
rs5739475786:28,333,514C/Tuncertain significance
rs3696212396:28,333,524A/Guncertain significance
rs7620127806:28,333,623C/Auncertain significance
rs7547489136:28,333,638A/Guncertain significance
rs13533652496:28,333,668G/Cuncertain significance
rs24807667736:28,333,679A/Guncertain significance
rs9465125216:28,334,003A/Guncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.