ZNF589
zinc finger protein 589
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants24 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs9847953 | 3:48,282,695 | A/G | — | benign |
| rs144306767 | 3:48,289,176 | G/A | — | benign |
| rs371763958 | 3:48,292,592 | C/G | — | — |
| rs62263025 | 3:48,295,311 | A/T | downstream gene variant | — |
| rs758522436 | 3:48,302,306 | C/A | — | uncertain significance |
| rs201589977 | 3:48,302,340 | C/T | — | uncertain significance |
| rs1575294987 | 3:48,302,417 | C/T | — | likely benign |
| rs770143133 | 3:48,309,441 | G/A | — | uncertain significance |
| rs773502823 | 3:48,309,442 | C/G | — | uncertain significance |
| rs768238552 | 3:48,309,608 | G/A | — | uncertain significance |
| rs933588108 | 3:48,309,618 | G/T | — | uncertain significance |
| rs760949090 | 3:48,309,632 | G/A | — | uncertain significance |
| rs1000419319 | 3:48,309,653 | A/T | — | uncertain significance |
| rs2034043032 | 3:48,309,720 | G/T | — | uncertain significance |
| rs2528941228 | 3:48,309,800 | G/A | — | uncertain significance |
| rs11718329 | 3:48,309,828 | C/G | — | benign |
| rs755852556 | 3:48,309,838 | G/C | — | uncertain significance |
| rs202092368 | 3:48,309,944 | C/T | — | likely benign |
| rs760276637 | 3:48,310,005 | C/T | — | uncertain significance |
| rs897789956 | 3:48,310,016 | G/A | — | uncertain significance |
| rs71323392 | 3:48,310,055 | C/T | — | likely benign |
| rs199524011 | 3:48,310,206 | G/A | — | uncertain significance |
| rs546281978 | 3:48,310,242 | A/C | — | benign |
| rs376706270 | 3:48,310,245 | C/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.