ZP1
zona pellucida glycoprotein 1
Summary
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility. [provided by RefSeq, May 2014]
Known Variants66 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1428659826 | 11:60,635,048 | C/T | — | uncertain significance |
| rs550479 | 11:60,635,091 | T/C | — | benign |
| rs765989327 | 11:60,635,092 | G/A | — | uncertain significance |
| rs759025727 | 11:60,635,099 | T/C | — | uncertain significance |
| rs2496133485 | 11:60,635,101 | G/A | — | uncertain significance |
| rs779268622 | 11:60,635,106 | G/A | — | uncertain significance |
| rs762724638 | 11:60,635,158 | G/A | — | uncertain significance |
| rs140966353 | 11:60,636,633 | G/A | — | conflicting classifications of pathogenicity |
| rs2496136630 | 11:60,636,637 | T/A | — | uncertain significance |
| rs145067883 | 11:60,636,698 | G/A | — | likely benign |
| rs115721019 | 11:60,636,706 | G/A | — | benign |
| rs2496136942 | 11:60,636,711 | A/C | — | uncertain significance |
| rs758199295 | 11:60,636,728 | G/C | — | uncertain significance |
| rs536327748 | 11:60,636,876 | G/A | — | — |
| rs145707301 | 11:60,637,010 | G/A | — | benign |
| rs199566234 | 11:60,637,062 | G/A | — | likely benign |
| rs754817594 | 11:60,637,082 | G/A | — | likely benign |
| rs377530078 | 11:60,637,103 | C/T | — | uncertain significance |
| rs559714951 | 11:60,637,134 | T/C | — | uncertain significance |
| rs489172 | 11:60,637,164 | C/T | — | benign |
| rs149325402 | 11:60,637,235 | C/G | — | uncertain significance |
| rs200151618 | 11:60,637,269 | C/A | — | uncertain significance |
| rs776515172 | 11:60,637,319 | C/T | — | pathogenic |
| rs1855541881 | 11:60,637,819 | C/G | — | uncertain significance |
| rs137927540 | 11:60,637,822 | G/A | — | uncertain significance |
| rs143390433 | 11:60,637,844 | G/A | — | uncertain significance |
| rs147134504 | 11:60,637,861 | G/A | — | uncertain significance |
| rs769509601 | 11:60,637,891 | C/T | — | pathogenic |
| rs10897122 | 11:60,638,461 | C/T | — | benign |
| rs372150345 | 11:60,638,472 | T/C | — | uncertain significance |
| rs1194231438 | 11:60,638,491 | G/C | — | uncertain significance |
| rs367708797 | 11:60,638,501 | A/G | — | uncertain significance |
| rs145848014 | 11:60,638,573 | G/A | — | uncertain significance |
| rs780866828 | 11:60,638,697 | G/A | — | uncertain significance |
| rs1348469808 | 11:60,638,708 | A/C | — | uncertain significance |
| rs1855562718 | 11:60,638,709 | T/C | — | uncertain significance |
| rs2134830455 | 11:60,638,712 | A/G | — | uncertain significance |
| rs199843782 | 11:60,638,778 | G/A | — | uncertain significance |
| rs2072098 | 11:60,640,480 | C/A | — | benign |
| rs763812579 | 11:60,640,645 | C/T | — | uncertain significance |
| rs141318014 | 11:60,640,660 | G/A | — | uncertain significance |
| rs1281635071 | 11:60,640,729 | G/A | — | uncertain significance |
| rs199611508 | 11:60,640,751 | G/A | — | uncertain significance |
| rs772172308 | 11:60,640,757 | C/T | — | uncertain significance |
| rs140265885 | 11:60,640,850 | G/A | — | uncertain significance |
| rs369535673 | 11:60,640,919 | G/A | — | uncertain significance |
| rs143715728 | 11:60,640,951 | C/T | — | likely benign |
| rs773898067 | 11:60,640,985 | G/A | — | conflicting classifications of pathogenicity |
| rs750703919 | 11:60,641,033 | G/A | — | uncertain significance |
| rs1590594990 | 11:60,641,038 | G/T | — | pathogenic |
| rs1354008897 | 11:60,641,143 | G/A | — | uncertain significance |
| rs199908546 | 11:60,641,153 | G/T | — | uncertain significance |
| rs2496155705 | 11:60,641,157 | G/A | — | uncertain significance |
| rs926042323 | 11:60,641,175 | C/T | — | uncertain significance |
| rs2074418 | 11:60,642,325 | G/A | — | benign |
| rs762797599 | 11:60,642,431 | C/T | — | uncertain significance |
| rs926892507 | 11:60,642,475 | A/C | — | uncertain significance |
| rs769799448 | 11:60,642,608 | G/A | — | uncertain significance |
| rs112864814 | 11:60,642,633 | C/T | — | benign |
| rs200866119 | 11:60,642,652 | A/C | — | uncertain significance |
| rs763617076 | 11:60,642,655 | G/A | — | pathogenic |
| rs371924805 | 11:60,642,665 | C/T | — | uncertain significance |
| rs532215581 | 11:60,642,673 | G/A | — | uncertain significance |
| rs1307369466 | 11:60,642,979 | T/C | — | pathogenic |
| rs557095250 | 11:60,643,027 | G/A | — | likely benign |
| rs2496163902 | 11:60,643,065 | T/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.