ZPBP

zona pellucida binding protein

Summary

ZPBP is one of several proteins that are thought to participate in secondary binding between acrosome-reacted sperm and the egg-specific extracellular matrix, the zona pellucida (McLeskey et al., 1998 [PubMed 9378618]).[supplied by OMIM, Aug 2008]

Known Variants27 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs759027473	7:49,914,602	T/A	—	—
rs141832800	7:49,977,123	C/T	—	likely benign
rs1452230016	7:49,977,185	T/A	—	uncertain significance
rs371753916	7:49,977,188	C/T	—	uncertain significance
rs192160335	7:49,992,310	G/A	intron variant	—
rs2128782038	7:50,022,968	G/A	—	pathogenic
rs775758667	7:50,022,985	C/A	—	uncertain significance
rs374373726	7:50,022,997	C/T	—	uncertain significance
rs988392	7:50,023,122	T/C	—	benign
rs139249676	7:50,057,919	A/G	—	benign
rs779275046	7:50,070,837	T/C	—	uncertain significance
rs140478650	7:50,070,873	G/C	—	benign
rs201491108	7:50,070,896	C/T	—	likely benign
rs190123663	7:50,070,915	A/C	—	likely benign
rs148913753	7:50,097,645	C/T	—	uncertain significance
rs76027725	7:50,097,697	A/G	—	benign
rs201273041	7:50,097,728	C/T	—	uncertain significance
rs79915261	7:50,121,392	C/T	—	likely benign
rs761959895	7:50,121,414	T/G	—	uncertain significance
rs1463701246	7:50,121,416	T/C	—	uncertain significance
rs369684234	7:50,121,444	G/A	—	uncertain significance
rs1168027289	7:50,129,221	A/C	—	likely benign
rs148222395	7:50,129,290	C/T	—	uncertain significance
rs778142618	7:50,132,714	G/A	—	uncertain significance
rs61696422	7:50,132,717	C/G	—	benign
rs202231065	7:50,132,741	C/G	—	benign
rs200431441	7:50,132,748	G/A	—	likely benign

Gene information from NCBI Gene. Variant classifications from ClinVar.