Gene Wizard vs Promethease: which raw DNA analysis tool in 2026?

Published August 9, 2026 · Updated August 10, 2026 · All Promethease claims sourced below

Disclosure: Gene Wizard is our product, so read this the way you'd read any vendor's comparison. To keep it useful, every factual claim about Promethease is cited and dated in the sources, and the table calls out the rows where Promethease genuinely comes out ahead.

For a decade, Promethease was the default answer to “what do I do with my 23andMe raw data?” It matches your file against SNPedia, the community wiki of SNP research, and returns a report of every matching entry — tens of thousands of them. MyHeritage acquired both Promethease and SNPedia in 2019 [3]; since then SNPedia has seen little updating, and as of 2025 Promethease generates a one-time report, emails it to you, and immediately deletes both your file and the report from its servers [2].

Gene Wizard was built in that gap: a continuously updated knowledge base with literature extraction from new studies, plus the analyses a single-SNP wiki can't do — ancestry-aware polygenic risk scores, pharmacogenomic star alleles, ClinVar matching, and admixture estimation — in an interactive dashboard you can revisit.

The honest summary: Promethease still has the larger single-SNP corpus and the longer track record. Gene Wizard has the fresher science, the modern analyses, and a report you don't have to re-buy. The table below goes row by row.

Compared	Gene Wizard	Promethease
Price	$19.99 one-time — full report plus 10 uploads that never expire; free results preview	$25 per report, +$4 for each additional DNA file [1]
Knowledge base	Curated associations with ongoing literature extraction from newly published studies	SNPedia wiki — a large corpus, but largely unchanged since the 2019 MyHeritage acquisition [3]
Report format	Interactive dashboard you can revisit, filter, and explore; downloadable PDF reports	Static one-time report, emailed as an attachment [2]
Polygenic risk scores	Yes — normalized against ancestry-matched reference panels, with confidence intervals	Not offered; reports are single-SNP entries
Pharmacogenomics	Star-allele calling across 76 pharmacogenes, with published dosing-guideline references	Individual drug-related SNP entries only; no star-allele diplotypes
ClinVar annotations	Direct matches against ClinVar classifications, with review status shown	Only where individual SNPedia pages happen to cite ClinVar
Genetic ancestry	Admixture estimation across 26 reference populations (also calibrates the risk scores)	Not offered
Whole-genome (WGS) support	Yes — VCF, alongside 23andMe and AncestryDNA files	Yes — accepts files from many providers, including VCF
Single-SNP breadth	≈68,000 curated, sourced public variant pages	SNPedia's 100,000+ entries — still the larger single-SNP corpus
Track record	New — launched 2025	Operating for well over a decade; a known quantity
Data handling	Raw file parsed in memory, never stored; results auto-delete after 7 days and can be deleted anytime	DNA file and report “immediately and permanently deleted” after the report is emailed [2]
Updates as science advances	Re-run your file anytime using remaining upload credits against the current knowledge base	Each new snapshot requires purchasing another report

✓ full support · ◑ partial · ✗ not offered · [n] = source below

Which should you use?

Choose Promethease if…

You want the single largest raw dump of per-SNP literature entries and are comfortable digging through a dense static report yourself.
You value its decade-plus operating history over newer analyses.
You only ever want a one-time snapshot and don't plan to revisit results.

Choose Gene Wizard if…

You want research that reflects studies published after 2019, with each claim linked to its sources.
You want polygenic risk scores, pharmacogenomics, ClinVar matching, and ancestry — not only per-SNP lookups.
You want to preview results free, keep an interactive dashboard, and re-run your file as the science moves.

Try Gene Wizard on your own file

Free preview of your results; one-time $19.99 for the full report — no subscription. Your raw file is never stored.

Upload your data See demo results

Sources

Promethease pricing: “Most reports cost $25”, additional DNA files $4 each. promethease.com (retrieved August 10, 2026).
Promethease privacy policy: “Once your Report is generated and emailed to you as an attachment, your DNA Data File and the generated Report are immediately and permanently deleted from our servers.” promethease.com/privacy (retrieved August 10, 2026).
MyHeritage's 2019 acquisition of Promethease and SNPedia: MyHeritage announcement. SNPedia edit activity since then is minimal and its content largely reflects pre-2019 literature.