rs10025405

This is a 3 prime utr variant variant in the TLR3 gene.

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Research that mentions this SNP (1)

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The role of polymorphisms in Toll-like receptors and their associated intracellular signaling genes in measles vaccine immunity
AssociationN=764Ovsyannikova IG et al.(2011)· Human Genetics

This study examined associations between polymorphisms in 454 Toll-like receptor (TLR) and related signaling gene SNPs and measles vaccine-specific immune responses in 764 subjects. The major allele of TLR2 rs3804100 was associated with increased antibody response (660 vs. 892 mIU/ml, p=0.002), while TLR4 rs5030710 showed decreased response (2,209 vs. 830 mIU/ml, p=0.001). A MAP3K7 haplotype was associated with lower antibody levels (p=0.01), and TLR-related SNPs including rs3748022 (IKBKE Pro713Leu), rs1786704 (TIRAP), rs702966 (KIAA1542/IRF7), and others were associated with variations in measles-specific cytokine responses (IL-2, IL-6, IL-10, IFNα, IFNγ, IFNλ-1, TNFα).

Traits studied:IFNγ Elispot responseMeasles vaccine immunityMeasles-specific IFNα secretionMeasles-specific IFNγ secretionMeasles-specific IFNλ-1 secretionMeasles-specific IL-10 secretionMeasles-specific IL-2 secretionMeasles-specific IL-6 secretionMeasles-specific TNFα secretionMeasles-specific antibody response
PubMedDOIMetascience Observatory

About TLR3

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It thus plays a role in host defense against multiple viruses. [provided by RefSeq, Jul 2021]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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