rs10034228

badMag 4.5

This is a intergenic variant variant.

Key Literature Trait Associations

High-Grade Myopia

The C allele at rs10034228 in the intergenic MYP11 region on chromosome 4q25 is associated with increased susceptibility to high-grade myopia (spherical equivalent <= -6.0 diopters) in Han Chinese individuals. The locus falls within a gene desert containing expressed sequence tags; the precise molecular mechanism linking this variant to ocular axial elongation remains under investigation.

Li Z et al. “A genome-wide association study reveals association between common variants in an intergenic region of 4q25 and high-grade myopia in the Chinese Han population.” Human Molecular Genetics 20(14):2861-2868 (2011)

Allele C

OR 1.23

p 7.7e-13

Large GWAS

Gao Y et al. “Common variants in chromosome 4q25 are associated with myopia in Chinese adults.” Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (optometrists) (2012)

Allele C

OR 1.18

p 9.0e-3

N 2,307

Preliminary work

East Asian (Chinese)

Liu J et al. “Genotype-phenotype correlation and interaction of 4q25, 15q14 and MIPEP variants with myopia in southern Chinese population.” The British Journal of Ophthalmology (2021)

Allele C

OR 0.56

p 2.0e-3

N 1,462

Preliminary work

East Asian (southern Chinese Han)

Gene information from NCBI Gene. Variant classifications from ClinVar.

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