rs10037670

This is a intron variant variant in the SAP30L-AS1 gene.

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Research that mentions this SNP (1)

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Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction
AssociationN=7,188Mobascher A. et al.(2010)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

A genome-wide association study of 7,188 Caucasian individuals examined the genetic basis of behavioral disinhibition across five phenotypes (nicotine use, alcohol consumption, alcohol dependence, illicit drug use, and non-substance disinhibition) using 527,829 autosomal SNPs. While no variants reached genome-wide significance after multiple testing correction, rs1868152 showed association with illicit drug use (p = 4.9 × 10⁻⁸, beta = 15.68) and 13 additional SNPs showed consistent directional effects across multiple phenotypes. Biometric heritability estimates (49-70%) substantially exceeded GCTA common variant estimates (8-37%), indicating that much of the genetic architecture remains unaccounted for by common variants.

Traits studied:AggressionAlcohol consumptionAlcohol dependenceBehavioral disinhibitionConduct disorderIllicit drug useNicotine useNon-substance behavioral disinhibitionSmoking behavior
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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