rs10040267

This variant is located in the WWC1 gene.

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Research that mentions this SNP (1)

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A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study
AssociationN=2,857Ira Driscoll et al.(2019)· International Journal of Geriatric Psychiatry

A candidate gene association study of dementia risk in 2,857 older postmenopausal women from the Women's Health Initiative Memory Study examining 96 SNPs across five genes (APOE/TOMM40, BDNF, COMT, SORL1, KIBRA). The APOE/TOMM40 locus showed the strongest association (rs157582: OR=1.64, p=2.4×10⁻⁸ for probable dementia), with additional significant associations in COMT (rs737865), BDNF (rs1491850), and KIBRA (rs4320284, rs2241368, rs244904). Results support APOE/TOMM40 as a dementia risk locus and extend associations to COMT, BDNF, and KIBRA genes.

Traits studied:Alzheimer's diseaseCognitive impairmentMemoryMild cognitive impairmentProbable dementia
PubMedDOIMetascience Observatory

About WWC1

The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

View all WWC1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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