rs10042486
This is a upstream gene variant variant in the HTR1A gene.
▶ClinVar annotation
▶Research that mentions this SNP (1)
▶Case–control association study for 10 genes in patients with schizophrenia: influence of 5HTR1A variation rs10042486 on schizophrenia and response to antipsychoticsAssociationN=391Concetta Crisafulli et al.(2012)· European Archives of Psychiatry and Clinical Neuroscience
Case-control association study investigating 42 SNPs in 10 genes in 221 Korean schizophrenia inpatients and 170 healthy controls. The 5HTR1A variant rs10042486 showed significant association with schizophrenia (χ² = 11.32, p = 0.003) and clinical improvement on PANSS scores; subjects with TT genotype showed greater improvement than CC/CT carriers (F = 178.77, p = 0.002 for PANSS total; p < 0.001 for positive and negative subscales). No significant associations were found for the other 41 SNPs.
About HTR1A
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]
View all HTR1A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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