rs10108011

This comprehensive review examines the genomics of schizophrenia and pharmacogenomics of antipsychotic drugs, synthesizing evidence on over 200 genes associated with psychotic disorders. The authors discuss five categories of genes relevant to antipsychotic response: disease-associated genes, mechanism-of-action genes, drug metabolism genes (particularly CYP2D6, CYP2C19, CYP2C9, CYP3A4), drug transporter genes, and pleiotropic genes. The review details pharmacogenomic profiles of 20+ antipsychotic drugs and demonstrates significant ethnic and interindividual variation in drug metabolism phenotypes, with examples including CYP2D6 extensive metabolizers (55.71% of population), intermediate metabolizers (34.7%), poor metabolizers (2.28%), and ultra-rapid metabolizers (7.31%).

This study examined 55 polymorphisms in five calcineurin genes (PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2) in 102 young Chinese men for associations with cardiac phenotypes at baseline and training responsiveness after 18 weeks of endurance training. Key findings: rs3763679 in PPP3CB was significantly associated with resting heart rate at baseline; rs1879793, rs1075534, rs7430, rs2461483, and rs10108011 in PPP3CC were associated with cardiac output/stroke volume response to exercise; rs1407877 in PPP3R2 was associated with ejection fraction response at 50W.