rs10141896
This variant is located in the NFATC4 gene.
▶Research that mentions this SNP (1)
▶Polymorphisms of nucleotide factor of activated T cells cytoplasmic 2 and 4 and the risk of acute rejection following kidney transplantationAssociationN=200Zijie Wang et al.(2018)· World Journal of Urology
A retrospective case-control study of 200 kidney transplant recipients (69 with acute rejection, 131 stable) using next-generation sequencing to identify SNPs in NFATC2 and NFATC4 genes. Among 71 identified SNPs, rs2426295 in NFATC2 showed significant association with acute rejection in the heterozygous comparison model (AA vs. AC: OR = 0.43, 95% CI = 0.19–0.98, P = 0.045), with AA genotype carriers having increased susceptibility to post-transplant rejection.
About NFATC4
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
View all NFATC4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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