rs1014286

This is a protein-altering variant in the SLC9A4 gene.

▶

GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

serum ST2 amount

Ho JE et al. “Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.” The Journal of Clinical Investigation 123(10):4208-18 (2013)

Allele G

OR 0.11

p 3.0e-33

N 2,797

Large GWAS

About SLC9A4

Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in monoatomic cation transmembrane transport; regulation of intracellular pH; and transepithelial ammonium transport. Predicted to act upstream of or within gastric acid secretion and glandular epithelial cell development. Predicted to be located in basolateral plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all SLC9A4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Loading comments…