rs10152595

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

BMI-adjusted waist-hip ratio, asthma

Zhu Z et al. “Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank.” The Journal of Allergy and Clinical Immunology 145(2):537-549 (2020)
Allele C
OR —
p 1.0e-20
N 457,690
Major Consortium StudyLarge GWAS
European

BMI-adjusted waist-hip ratio, adult onset asthma

Zhu Z et al. “Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank.” The Journal of Allergy and Clinical Immunology 145(2):537-549 (2020)
Allele C
OR —
p 3.0e-20
N 457,690
Major Consortium StudyLarge GWAS
European

asthma

Zhu Z et al. “Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.” The European Respiratory Journal 54(6) (2019)
Allele C
OR 1.07
p 1.0e-19
N 394,283
Large GWAS
multi-ancestry
Olafsdottir TA et al. “Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis.” Nature Communications 11(1):393 (2020)
Allele C
OR 1.07
p 5.0e-19
N 771,388
Large GWAS
European
Jia G et al. “Discerning asthma endotypes through comorbidity mapping.” Nature Communications 13(1):6712 (2022)
Allele C
OR 0.93
p 2.0e-15
N 305,098
Large GWAS
multi-ancestry

BMI-adjusted waist-hip ratio

Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)
Allele C
OR 0.02
p 4.0e-11
N 315,284
Meta-analysisLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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