rs10152640
This is a protein-altering variant in the FSIP1 gene.
▶Research that mentions this SNP (1)
▶SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancerAssociationN=2,023Karagas MR et al.(2012)· Human Genetics
This case-control study of arsenic exposure and bladder cancer identified SNPs in FSIP1 (rs10152640, OR=12.20 for GG genotype in high arsenic group) and SLC39A2 (rs2234636, OR=2.96 for TC and 2.91 for CC genotypes) as potential genetic modifiers of arsenic-related bladder cancer risk in a US population with low to moderate drinking water arsenic exposure. Both associations were specific to high arsenic-exposed individuals and smokers, with significant gene-environment interactions.
About FSIP1
Predicted to act upstream of or within several processes, including axoneme assembly; homeostasis of number of cells within a tissue; and vesicle organization. Predicted to be active in acrosomal vesicle; nucleus; and sperm head. [provided by Alliance of Genome Resources, Jul 2025]
View all FSIP1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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