rs10159261

This is a coding sequence variant variant in the AGMAT gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

glomerular filtration rate

Wuttke M et al. “A catalog of genetic loci associated with kidney function from analyses of a million individuals.” Nature Genetics 51(6):957-972 (2019)

Allele T

OR 0.00

p 1.0e-27

N 765,348

Large GWAS

multi-ancestry

serum creatinine amount

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele T

OR 0.02

p 2.0e-19

N 450,015

Large GWAS

multi-ancestry

About AGMAT

Enables arginase activity; guanidinobutyrase activity; and guanidinopropionase activity. Predicted to be involved in putrescine biosynthetic process from arginine, via agmatine. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

View all AGMAT variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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