rs10168931

This variant is located in the ALMS1P1 gene.

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GWAS Catalog Trait Associations (22)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

blood N-acetylasparagine measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)

Allele A

OR 1.09

p —

N 7,935

Large GWAS

European

metabolite measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)

Allele A

OR 0.50

p —

N 14,296

Large GWAS

European

Tahir UA et al. “Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.” Nature Communications 13(1):4923 (2022)

Allele A

OR 0.54

p 3.0e-77

N 2,466

Large GWAS

multi-ancestry

methionine sulfone measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)

Allele A

OR 0.48

p —

N 14,296

Large GWAS

European

N-acetyl-1-methylhistidine measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)

Allele A

OR 0.91

p —

N 14,296

Large GWAS

European

Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)

Allele A

OR 0.80

p 5.0e-303

N 8,644

Large GWAS

multi-ancestry

N-acetylarginine measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)

Allele A

OR 1.01

p —

N 14,296

Large GWAS

European

Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)

Allele A

OR 0.89

p 5.0e-303

N 9,179

Large GWAS

multi-ancestry

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)

Allele A

OR 1.03

p —

N 8,271

Large GWAS

European

N-acetylglutamine measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)

Allele A

OR 0.94

p —

N 8,181

Large GWAS

European

N-acetylphenylalanine measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)

Allele A

OR 0.66

p —

N 8,228

Large GWAS

European

Rhee EP et al. “Trans-ethnic genome-wide association study of blood metabolites in the Chronic Renal Insufficiency Cohort (CRIC) study.” Kidney International 101(4):814-823 (2022)

Allele A

OR 0.39

p 7.0e-13

N 687

Small GWAS

African American or Afro-Caribbean

N-acetyltyrosine measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)

Allele A

OR 0.73

p —

N 14,296

Large GWAS

European

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)

Allele A

OR 0.77

p —

N 7,841

Large GWAS

European

Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)

Allele A

OR 0.61

p 3.0e-240

N 7,690

Large GWAS

multi-ancestry

N-delta-acetylornithine measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)

Allele A

OR 0.91

p —

N 14,296

Large GWAS

European

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)

Allele A

OR 0.94

p —

N 8,259

Large GWAS

European

Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)

Allele A

OR 0.91

p 5.0e-303

N 7,872

Large GWAS

multi-ancestry

Wang C et al. “Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits.” Nature Genetics 56(12):2685-2695 (2024)

Allele A

OR 0.19

p 8.0e-23

N 1,016

Large GWAS

European

urinary metabolite measurement

Schlosser P et al. “Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans.” Nature Genetics 52(2):167-176 (2020)

Allele A

OR 0.89

p —

N 1,221

Large GWAS

This variant is in our database but has no known associations or PRS memberships yet.

rs10168931

GWAS Catalog Trait Associations (22)

blood N-acetylasparagine measurement

metabolite measurement

methionine sulfone measurement

N-acetyl-1-methylhistidine measurement

N-acetylarginine measurement

N-acetylglutamine measurement

N-acetylphenylalanine measurement

N-acetyltyrosine measurement

N-delta-acetylornithine measurement

urinary metabolite measurement

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