rs1017412
This is a intergenic variant variant in the NTRK3 gene.
▶Research that mentions this SNP (1)
▶Neurotrophic factor‐related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high‐risk male populationAssociationN=143Conner AC et al.(2008)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
A candidate gene association study examined six SNPs in neurotrophic factor genes (NTF3, NTRK2, NTRK3, BDNF, p75NTR) for association with adult ADHD scores in 143 high-risk males from a forensic psychiatric unit. While no SNPs showed significant association after Bonferroni correction, rs6332 in NTF3 exon III showed a trend toward association with increased ADHD scores (P=0.05 for WURS-k; P=0.03 for Wender-Reimherr interview), suggesting the A-allele may be a potential risk factor.
About NTRK3
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
View all NTRK3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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