rs10183150

This is a regulatory region variant variant in the LONRF2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

mathematical ability

Lee JJ et al. “Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.” Nature Genetics 50(8):1112-1121 (2018)

Allele A

OR 0.02

p 3.0e-16

N 430,445

Large GWAS

European

About LONRF2

Predicted to enable misfolded protein binding activity; ribonucleoprotein complex binding activity; and ubiquitin protein ligase activity. Predicted to act upstream of or within several processes, including motor behavior; neuron differentiation; and protein quality control for misfolded or incompletely synthesized proteins. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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