rs1018351

This variant is located in the IGSF5 gene.

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Research that mentions this SNP (1)

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Genetic and epigenetic analysis of SSAT gene dysregulation in suicidal behavior
ReviewMichel Guipponi et al.(2009)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This is a comprehensive review of post-mortem brain tissue studies examining the neurobiology of suicidal behavior. The paper synthesizes findings on genetic studies, proteomics, neurotransmitter systems (serotonergic, noradrenergic, dopaminergic, glutamatergic), cell signaling, neural plasticity, and neuroendocrinology associated with suicide. Key genetic variants discussed include COMT val158met, TPH2 rs1386494, ADRA2B rs1018351, SLC6A3 rs403636, SAT1 rs6526342, HTR2C Cys23Ser, BDNF Val66Met, and 5-HTTLPR polymorphism.

Traits studied:Bipolar disorderDepressionMajor depressionPsychiatric disordersSchizophreniaSuicidal behaviorSuicide
PubMedDOIMetascience Observatory

About IGSF5

Predicted to enable PDZ domain binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be located in apical plasma membrane. Predicted to be active in bicellular tight junction and cell surface. [provided by Alliance of Genome Resources, Apr 2025]

View all IGSF5 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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