rs10197862

This is a intron variant variant in the IL1RL1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

asthma

Han Y et al. “Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.” Nature Communications 11(1):1776 (2020)
Allele A
OR 1.19
p 4.0e-93
N 303,859
Large GWAS
European

asthma, seasonal allergic rhinitis

Ferreira MA et al. “Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.” The Journal of Allergy and Clinical Immunology 133(6):1564-71 (2014)
Allele A
OR 1.24
p 4.0e-11
N 20,776
Large GWAS
European

About IL1RL1

The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

View all IL1RL1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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