rs10208293

This is a intron variant variant in the IL1RL1 gene.

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

eosinophil count

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)
Allele A
OR 0.07
p 3.0e-152
N 408,112
Large GWAS
European
Höglund J et al. “Gene-Based Variant Analysis of Whole-Exome Sequencing in Relation to Eosinophil Count.” Frontiers in Immunology 13:862255 (2022)
Allele A
OR 0.08
p 2.0e-87
N 365,954
Large GWAS
European
Kachuri L et al. “Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.” American Journal of Human Genetics 108(10):1823-1835 (2021)
Allele A
OR —
p 1.0e-96
N 234,763
Large GWAS
European

interleukin-1 receptor-like 1 measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele A
OR 0.26
p 5.0e-80
N 10,708
Large GWAS
European

childhood onset asthma

Pividori M et al. “Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.” The Lancet. Respiratory Medicine 7(6):509-522 (2019)
Allele G
OR 1.14
p 4.0e-38
N 327,670
Large GWAS
European

asthma

Pividori M et al. “Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.” The Lancet. Respiratory Medicine 7(6):509-522 (2019)
Allele G
OR —
p 1.0e-15
N 37,846
Large GWAS
European

nasal disorder

Saarentaus EC et al. “Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation.” Nature Communications 14(1):83 (2023)
Allele A
OR 0.91
p 4.0e-15
N 224,443
Large GWAS
European

level of bone marrow proteoglycan in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.04
p 8.0e-13
N 47,745
Large GWAS
European

asthma, age at onset

Sarnowski C et al. “Identification of a new locus at 16q12 associated with time to asthma onset.” The Journal of Allergy and Clinical Immunology 138(4):1071-1080 (2016)
Allele G
OR 1.14
p 3.0e-8
N 13,886
Large GWAS
European

About IL1RL1

The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

View all IL1RL1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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