rs1024905

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

migraine disorder

Gormley P et al. “Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.” Nature Genetics 48(8):856-66 (2016)
Allele G
OR 1.06
p 2.0e-17
N 375,752
Meta-analysisLarge GWAS
European

migraine without aura, susceptibility to, 4

Gormley P et al. “Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.” Nature Genetics 48(8):856-66 (2016)
Allele G
OR 1.12
p 3.0e-9
N 147,970
Meta-analysisLarge GWAS
European
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Research that mentions this SNP (1)

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Using a Genetic Risk Score Approach to Predict Headache Response to Triptans in Migraine Without Aura
AssociationN=172Sarah Cargnin et al.(2019)· The Journal of Clinical Pharmacology

A genetic risk score combining risk alleles at TRPM8 rs6724624 and FGF6 rs1024905 was inversely associated with inconsistent response to triptans in 172 migraine without aura (MwoA) patients (OR 0.62, 95% CI 0.43-0.89, FDR q=0.045). Adding this 2-SNP genetic risk score to a triptan-adjusted model significantly improved discrimination accuracy from AUC 0.57 to 0.64 (P=0.037), suggesting potential utility for predicting poor triptan responders.

Traits studied:Migraine without auraTriptan response
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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