rs10278040

This is a downstream gene variant variant.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

androsterone sulfate measurement

Shin SY et al. “An atlas of genetic influences on human blood metabolites.” Nature Genetics 46(6):543-550 (2014)

Allele A

OR —

β 0.361

p 9.0e-113

N 7,785

Large GWAS

European

X-21410 measurement

Hysi PG et al. “Metabolome Genome-Wide Association Study Identifies 74 Novel Genomic Regions Influencing Plasma Metabolites Levels.” Metabolites 12(1) (2022)

Allele A

OR 0.36

p 4.0e-34

N 8,809

Large GWAS

European

5alpha-androstan-3beta,17beta-diol disulfate measurement

Shin SY et al. “An atlas of genetic influences on human blood metabolites.” Nature Genetics 46(6):543-550 (2014)

Allele A

OR —

β 0.190

p 1.0e-29

N 7,345

Large GWAS

European

dehydroepiandrosterone sulphate measurement

Pott J et al. “Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease.” The Journal of Clinical Endocrinology and Metabolism 104(11):5008-5023 (2019)

Allele A

OR 0.19

p 3.0e-12

N 7,659

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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