rs1034576

This is a intron variant variant.

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Research that mentions this SNP (1)

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Response to Methadone Maintenance Treatment is Associated with the MYOCD and GRM6 Genes
AssociationN=116Francina Fonseca et al.(2010)· Molecular Diagnosis & Therapy

This case-control association study examined 116 opioid-dependent patients in methadone maintenance treatment (MMT) to identify genetic variants associated with treatment response. The study found significant epistatic interactions between rs1714984 (MYOCD) and rs953741 (GRM6), where carriers of the A allele at rs1714984 combined with the AG genotype at rs953741 showed increased risk of being nonresponders (OR=10.83, 95% CI 2.52-46.66, p=0.006). The study also identified rs1861591 (CRY1) as individually associated with nonresponder status (OR=2.99, p=0.035), though this did not survive multiple testing correction.

Traits studied:Heroin addictionMethadone maintenance treatment responseOpioid dependence
DOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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