rs1035142

This variant is located in the FLACC1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neutrophil percentage of leukocytes

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele G

OR 0.03

p 7.0e-12

N 171,542

Large GWAS

European

breast carcinoma

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.12

p 3.0e-9

N 79,550

Large GWAS

East Asian

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Research that mentions this SNP (1)

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Fas/FasL, Bcl2 and Caspase-8 gene polymorphisms in Chinese patients with rheumatoid arthritis

AssociationN=1,454Aiping Zhu et al.(2016)· Rheumatology International

This Chinese case-control study (615 RA patients, 839 controls) investigated associations between five apoptosis-related gene polymorphisms and rheumatoid arthritis susceptibility. Fas rs2234767 G/A and Bcl2 rs17757541 C/G were identified as risk factors for RA. FasL rs763110 C/T, Bcl2 rs12454712 T/C, and Caspase-8 rs1035142 G/T showed no association in the primary study. A meta-analysis including four studies (914 cases, 1128 controls) found no significant association overall for FasL rs763110 C/T with RA, but stratification analysis revealed increased risk among Caucasian patients.

Traits studied:Rheumatoid arthritis

PubMed DOI Metascience Observatory

About FLACC1

Predicted to be located in cytoplasmic vesicle and outer dense fiber. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]