rs10401670

This is a upstream gene variant variant in the MCEMP1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

resistin measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.16
p 2.0e-196
N 47,745
Large GWAS
European
Folkersen L et al. “Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.” Nature Metabolism 2(10):1135-1148 (2020)
Allele C
OR 0.16
p 2.0e-64
N 21,758
Large GWAS
European
Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele C
OR 0.15
p 2.0e-27
N 10,708
Large GWAS
European
Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele C
OR 0.19
p 9.0e-12
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)
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Research that mentions this SNP (1)

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Common quantitative trait locus downstream of RETN gene identified by genome‐wide association study is associated with risk of type 2 diabetes mellitus in Han Chinese: a Mendelian randomization effect
AssociationN=4,341Chia‐Min Chung et al.(2014)· Diabetes/Metabolism Research and Reviews

This genome-wide association study identified two SNPs (rs3745367 and rs1423096) in the RETN gene associated with circulating resistin levels in Han Chinese hypertensive subjects. Using Mendelian randomization in an independent cohort (CVDFACTS), rs1423096 was significantly associated with metabolic syndrome risk (OR=2.21, p=0.0034) and type 2 diabetes mellitus (OR=1.62, p=0.0063), providing evidence that resistin causally contributes to T2DM development.

Traits studied:HDL-C levelsHypertensionInsulin resistanceMetabolic syndromeResistin levelsType 2 diabetes mellitus
PubMedDOIMetascience Observatory

About MCEMP1

This gene encodes a single-pass transmembrane protein. Based on its expression pattern, it is speculated to be involved in regulating mast cell differentiation or immune responses. [provided by RefSeq, Jul 2008]

View all MCEMP1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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