rs10406069

This is a protein-altering variant in the CD22 gene.

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Research that mentions this SNP (1)

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The association of common polymorphisms in miR-196a2 with waist to hip ratio and miR-1908 with serum lipid and glucose
AssociationN=73,014Mohsen Ghanbari et al.(2015)· Obesity

Two miRNA genetic variants were identified as significantly associated with cardiometabolic phenotypes: rs11614913 in miR-196a2 associated with waist-to-hip ratio (P=1.7e-25), and rs174561 in miR-1908 associated with lipid and glucose traits. Functional analyses revealed these variants affect pre-miRNA processing and regulate target genes involved in fat distribution and lipid metabolism.

Traits studied:HDL-cholesterolLDL-cholesterolblood pressurebody mass indexcardiometabolic phenotypesfasting glucosetotal cholesteroltriglycerideswaist-to-hip ratio
PubMedDOIMetascience Observatory

About CD22

Predicted to enable CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in B cell activation; negative regulation of B cell receptor signaling pathway; and regulation of endocytosis. Located in early endosome and recycling endosome. Implicated in diffuse large B-cell lymphoma. [provided by Alliance of Genome Resources, Jul 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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