rs10411161

A hospital-based case-control study in rural and urban India (1,204 cases; 1,212 controls) examined genetic and lifestyle risk factors for breast cancer. Four SNPs in FGFR2 (rs1219648, rs2420946, rs2981575, rs2981582) showed positive associations with breast cancer (ORs 1.32-1.47). Additional SNPs in obesity and metabolic genes (rs374748 in FBN2, rs2922763 in HNF4G, rs2116830 in KCNMA1, rs11121832 in MTHFR, rs16886165 in MAP3K1, rs11594610 in TCF7L2, rs2274459 in MLN) were associated with increased breast cancer risk. Waist-to-hip ratio ≥0.95 showed strong association (OR 3.78; 95% CI 2.92-4.89), and women living first 20 years in rural areas showed protective effect (OR 0.77).

A two-stage genome-wide association study (GWAS) identified six novel breast cancer susceptibility loci in a Canadian cohort (3,064 total participants). In Stage I, 348 cases and 348 controls were genotyped on Affymetrix SNP 6.0 arrays (906,600 SNPs), with 35 candidate variants selected for replication in Stage II (1,153 cases and 1,215 controls). Six SNPs showed significant association with breast cancer: rs1092913 in ROPN1L (OR 1.45, p=1.89×10⁻⁶), three ZNF577 SNPs (rs10411161, rs3848562, rs11878583; ORs 1.35-1.42), rs1429142 near EDNRA (OR 1.27), and rs1981867 near C16orf61 (OR 1.22). While not significant after genome-wide correction, these represent potential novel candidate loci warranting further validation.