rs1044432
This is a downstream gene variant variant in the BTBD10 gene.
▶Research that mentions this SNP (1)
▶Functional polymorphisms in circadian positive feedback loop genes predict postsurgical prognosis of gastric cancerAssociationN=704Yibing Chen et al.(2019)· Cancer Medicine
This association study examined nine functional SNPs in circadian positive feedback loop genes (CLOCK, BMAL1, NPAS2) in 704 Chinese gastric cancer patients. Three SNPs showed significant associations with overall survival and recurrence-free survival: rs11133399 in CLOCK (HR 1.27-1.29, p=0.007-0.020), rs2279284 in BMAL1 (HR 1.12-1.18, p=0.024-0.048), and rs1044432 in BMAL1 (HR 0.82-0.84, p=0.042-0.047). Functional assays confirmed that the G allele of rs11133399 enhanced CLOCK promoter activity and gene expression.
About BTBD10
Predicted to be involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and type B pancreatic cell proliferation. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
View all BTBD10 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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