rs10459953

This variant is located in the NOS2 gene.

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Research that mentions this SNP (2)

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NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans
AssociationN=766Velez DR et al.(2009)· Human Genetics

A case-control association study in African-Americans (279 cases, 166 controls) and Caucasians (198 cases, 123 controls) examined 39 SNPs in the NOS2A gene for pulmonary tuberculosis susceptibility. Ten NOS2A SNPs were associated with TB in African-Americans, with the strongest associations at rs2274894 (OR=1.84, 95% CI 1.23-2.77, p=0.003) and rs7215373 (OR=1.67, 95% CI 1.17-2.37, p=0.004). Strong gene-gene interactions were observed between NOS2A SNPs and variants in IFNGR1 and TLR4 genes, suggesting synergistic effects on TB susceptibility.

Traits studied:Pulmonary TBTuberculosis
PubMedDOIMetascience Observatory
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Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome
AssociationN=316Juliane Winkelmann et al.(2008)· Movement Disorders

This prospective study of 316 HIV-positive adults identified genetic associations between inflammatory gene polymorphisms and Restless Legs Syndrome (RLS). Four IL1B SNPs (rs1143643, rs1143634, rs1143633, rs1071676) were significantly associated with RLS, with carriers of the minor allele having increased likelihood of RLS diagnosis (OR 2.56-10.3), explaining 15-17% of variance. IL17A rs8193036 was also significantly associated (OR 2.20, explaining 16% of variance) in adjusted logistic regression models.

Traits studied:Restless Legs Syndrome
PubMedDOIMetascience Observatory

About NOS2

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

View all NOS2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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