rs10465885

This case-control study of 381 Chinese Han patients (185 with atrial fibrillation, 196 controls) investigated associations between ion channel-related gene polymorphisms and AF risk. Three SNPs were significantly associated with AF: rs8134775 near KCNE2 conferred decreased AF risk (OR = 0.70; p = 0.034), rs35594137 in GJA5 conferred decreased AF risk in the recessive model (OR = 0.40; p = 0.018), and rs8079702 near KCNJ2 conferred increased AF risk in the recessive model (OR = 2.31; p = 0.012).

A two-stage genome-wide association study (GWAS) in Spanish population identified KLF12 as a new susceptibility locus for rheumatoid arthritis, with rs1324913 showing stronger association (P=0.01) in replication than PTPN22 rs2476601. Joint analysis with three previous GWAS studies confirmed KLF12 and PTPRT as commonly associated loci, with KLF12 SNP rs1887346 and rs9318228 showing P values of 6.03×10⁻⁵ and 3.66×10⁻⁵ in the discovery phase and evidence of replication across multiple populations.