rs10482672
This is a regulatory region variant variant in the NR3C1 gene.
▶Research that mentions this SNP (1)
▶Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control TrialAssociationN=490Albert D. et al.(2015)· Journal of Policy Analysis and Management
This genetic analysis of the Fast Track randomized controlled trial examined whether variants of the glucocorticoid receptor gene NR3C1 predicted response to a 10-year behavioral intervention in high-risk children. In European-American children (N=242), rs10482672 A allele carriers showed dramatic differential response: 18% of treated A carriers vs 75% of control A carriers developed externalizing psychopathology by age 25, while non-carriers showed no intervention effect (56% treated vs 57% control), demonstrating gene-by-intervention interaction (δ=-0.520, p=0.00006). No genetic moderation effects were found in African-American participants (N=248).
About NR3C1
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
View all NR3C1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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