rs10483028
This is a intron variant variant.
▶Research that mentions this SNP (1)
▶Identification of New Genetic Susceptibility Loci for Breast Cancer Through Consideration of Gene‐Environment InteractionsAssociationN=69,261Anja Schoeps et al.(2014)· Genetic Epidemiology
This large gene-environment interaction study of 34,475 breast cancer cases and 34,786 controls identified three novel breast cancer susceptibility loci through analysis of 71,527 SNPs. Two SNPs (rs10483028 and rs2242714) on chromosome 21q22.12 showed significant interaction with body mass index, with rs10483028 conferring increased risk in leaner women (OR=1.26, 95% CI 1.15-1.38 for BMI<25) but not in obese women (OR=0.89, 95% CI 0.72-1.11 for BMI≥30), while rs12197388 in ARID1B on chromosome 6 showed interaction with age at menarche and parity (P=3×10⁻⁷).
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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