rs10490046

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)

Allele C

OR 0.01

p 2.0e-26

N 5,314,291

Large GWAS

European, Hispanic or Latin American, East Asian, African unspecified, South Asian

heel bone mineral density

Morris JA et al. “An atlas of genetic influences on osteoporosis in humans and mice.” Nature Genetics 51(2):258-266 (2019)

Allele A

OR 0.02

p 1.0e-20

N 426,824

Large GWAS

European

Kemp JP et al. “Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis.” Nature Genetics 49(10):1468-1475 (2017)

Allele A

OR 0.03

p 3.0e-17

N 142,487

Large GWAS

European

bone tissue density

Qian 钱雨 Y et al. “Genome-wide Association Studies of over 30,000 Samples with Bone Mineral Density at Multiple Skeletal Sites and Its Clinical Relevance.” Genomics, Proteomics & Bioinformatics 23(5) (2025)

Allele C

OR 0.08

p 1.0e-16

N 31,986

Large GWAS

European

Medina-Gomez C et al. “Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.” American Journal of Human Genetics 102(1):88-102 (2018)

Allele C

OR —

β 0.042

p 1.0e-8

N 66,945

Meta-analysisLarge GWAS

multi-ancestry

Medina-Gomez C et al. “Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis.” Communications Biology 6(1):691 (2023)

Allele C

OR —

β 0.064

p 1.0e-14

N 43,832

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs10490046

GWAS Catalog Trait Associations (3)

body height

heel bone mineral density

bone tissue density

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