rs10490624
This is a regulatory region variant variant in the INSIG2 gene.
About INSIG2
The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]
View all INSIG2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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