rs10497529
This variant is located in the CCDC141 gene.
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
pulse pressure measurement
Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)
Allele A
OR 0.37
p 5.0e-15
N 1,028,980
Large GWAS
multi-ancestry
maximal oxygen uptake measurement
Hanscombe KB et al. “The genetic case for cardiorespiratory fitness as a clinical vital sign and the routine prescription of physical activity in healthcare.” Genome Medicine 13(1):180 (2021)
Allele G
OR 0.09
p 1.0e-11
N 70,783
Large GWAS
European
diastolic blood pressure
Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)
Allele A
OR 0.24
p 2.0e-9
N 1,028,980
Large GWAS
multi-ancestry
left ventricular mass index
Khurshid S et al. “Clinical and genetic associations of deep learning-derived cardiac magnetic resonance-based left ventricular mass.” Nature Communications 14(1):1558 (2023)
Allele G
OR 1.28
p 2.0e-9
N 43,230
Large GWAS
multi-ancestry
heart rate response to exercise
Ramírez J et al. “Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.” Nature Communications 9(1):1947 (2018)
Allele G
OR 0.97
p 3.0e-9
N 67,257
Large GWAS
European
heart rate
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.08
p 9.0e-56
N 394,642
Large GWAS
European
Eppinga RN et al. “Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.” Nature Genetics 48(12):1557-1563 (2016)
Allele G
OR 1.10
p 1.0e-22
N 134,251
Large GWAS
multi-ancestry
Ramírez J et al. “Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.” Nature Communications 9(1):1947 (2018)
Allele G
OR —
p 5.0e-15
N 67,062
Large GWAS
European
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.12
p 1.0e-18
N 57,990
Major Consortium StudyLarge GWAS
Hispanic or Latin American
▶ClinVar annotation
Benign★★★☆
2 submitters2 publicationsAbout CCDC141
Predicted to be involved in brain development. Predicted to act upstream of or within centrosome localization and cerebral cortex radially oriented cell migration. Predicted to be located in centrosome and cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
View all CCDC141 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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