rs10502

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

tumor necrosis factor ligand superfamily member 10 amount

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.05
p 8.0e-21
N 47,745
Large GWAS
European

level of cholinesterase in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.04
p 2.0e-18
N 47,745
Large GWAS
European
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Research that mentions this SNP (1)

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GABRR1andGABRR2, encoding the GABA‐A receptor subunits ρ1 and ρ2, are associated with alcohol dependence
AssociationN=1,923Xiaoling Xuei et al.(2010)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Family-based association study of GABRR1 and GABRR2 (GABA-A receptor ρ1 and ρ2 subunits) with alcohol dependence in 1,923 European Americans from 219 multiplex families. Six SNPs were significantly associated with DSM-IV alcohol dependence (p<0.05), with rs282129 (Met430Thr coding SNP in GABRR2, p=0.03) being notable. Associations were strongest in individuals with early-onset alcohol dependence (age ≤21), with 16 SNPs showing significant association in this subgroup.

Traits studied:Alcohol dependenceAlcoholism
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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