rs1050283

This is a 3 prime utr variant variant in the OLR1 gene.

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Research that mentions this SNP (1)

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Analysis of a polymorphic microRNA target site in the purinergic receptor P2RX7 gene
ReviewOmar Abdul Rahman et al.(2010)· ELECTROPHORESIS

This narrative review examines the role of microRNAs (miRNAs) in neuropsychiatric disorders including schizophrenia, bipolar disorder, major depression, Alzheimer's disease, and Parkinson's disease. The paper synthesizes studies on miRNA expression alterations in peripheral tissues and genetic variants in miRNA-related genes (SNPs in miRNAs, miRNA target genes, and miRNA processing genes), highlighting the potential of miRNAs as biomarkers for diagnosis and prognosis of brain diseases.

Traits studied:Alzheimer's diseaseAnxiety disorderBipolar disorderFrontotemporal lobar degenerationMajor depressionMild cognitive impairmentObsessive-compulsive disorderPanic disorderParkinson's diseaseSchizophreniaTourette's syndrome
PubMedDOIMetascience Observatory

About OLR1

This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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