rs10505476

This case-only study of 2,147 men (1,060 African Americans, 1,087 European Americans) examined whether GWAS-identified prostate cancer susceptibility SNPs are associated with disease aggressiveness. Four GWAS replication SNPs (rs2660753, rs13254738, rs10090154, rs2735839) and 7 flanking SNPs showed significant association (P<0.05) with prostate cancer aggressiveness across 3 genomic regions (3p12, 8q24, and 19q13). The KLK3 SNPs were notably associated with PSA levels in African Americans (p<0.001) and Gleason score in both populations, though associations were not consistent across racial groups.

This GWAS replication study evaluated 800 SNPs in African American (n=417) and European American (n=455) prostate cancer cases versus controls (n=925 AA, n=1,687 EA) from the NC-LA Prostate Cancer Project. Of 32 European-based GWAS SNPs, 13 were significant at P<0.05 in European Americans and 4 in African Americans (rs6983267, rs7017300, rs1859962, rs6501455). Two additional SNPs reached study-wide significance: rs1472606 (OR=1.43 in EA) and rs9351265 (OR=1.48 in AA). The study confirms a large proportion of cancer-associated regions from European GWAS but shows limited predictive value (AUC=0.60 in EA, 0.56 in AA) for clinical screening.

This case-control study investigated 15 SNPs at the 8q24 locus for association with testicular germ cell tumors (TGCT) using 568 cases and 680 controls from the STEED military study. Overall, no significant associations were found between 8q24 SNPs and TGCT risk. However, nonseminomas showed three tentative associations: rs6470494 (OR=1.68 for GG genotype, p=0.04), rs13254738 (OR=1.62 for TT genotype, p=0.07), and an inverse association with rs10505476 (OR=0.67 for CT genotype, p=0.04).