rs10519262
This is a intron variant variant in the ATP8B4 gene.
▶Research that mentions this SNP (1)
▶GAB2 as an Alzheimer Disease Susceptibility GeneAssociationN=4,007Brit-Maren M. Schjeide et al.(2009)· Archives of Neurology
This follow-up study of genomewide association findings tested 4 putative Alzheimer's disease susceptibility loci from prior GWA studies in 4,007 DNA samples from 1,299 families with AD. Only rs7101429 in GAB2 showed significant evidence of association (P = .002), with a protective effect (OR = 0.76, 95% CI 0.62-0.94). The other 3 loci (GOLM1, chromosome 15q, and chromosome 9p) did not show consistent evidence of association across the datasets.
About ATP8B4
This gene encodes a member of the cation transport ATPase (P-type) family and type IV subfamily. The encoded protein is involved in phospholipid transport in the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
View all ATP8B4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…