rs1052133

A study of 559 men with prostate cancer examined associations between circulating carotenoid levels and high-grade prostate cancer risk, finding that higher carotenoid levels (α-carotene OR=0.34, β-carotene OR=0.31, lycopene OR=0.55) were inversely associated with high-grade disease. SNPs in XRCC1 (rs25489), SOD3 (rs699473), and OGG1 (rs1052133) modified these associations, and lycopene levels were associated with lower genomic instability in low-grade tumors.

This candidate gene study examined 73 SNPs in 10 selenoprotein and antioxidant genes among 568 men with non-metastatic prostate cancer treated with radical prostatectomy. Plasma selenium was not associated with high-grade prostate cancer or recurrence. Less common alleles of rs11913319 (TXNRD2, OR=2.01) and rs125701 (OGG1, OR=1.72) were associated with increased risk of high-grade prostate cancer. Multiple SNPs in TXNRD1, TXNRD2, GPX3, and SEP15 showed associations with prostate cancer recurrence, though none remained significant after Bonferroni correction.

A case-control study of 988 bladder cancer cases and 1,004 controls from Los Angeles and Shanghai examined 632 tagSNPs in 28 DNA repair genes across four pathways. Key findings include associations between POLB rs7832529 (OR=1.5, p=0.003) and bladder cancer risk among Chinese, XPC SNPs (rs2607734, rs2279017, rs2228001) among Chinese males, and OGG1 SNPs among Chinese females. XRCC6 rs2284082 showed significant interaction with smoking (p=0.001).

This review examines the role of oxidative DNA damage and its repair via base excision repair (BER) glycosylases (hOGG1, MUTYH, NEIL1-3, NTH1) in sporadic colorectal cancer (CRC) pathogenesis, prognosis, and treatment. The authors discuss hereditary syndromes (MUTYH-associated polyposis, NTHL1-associated tumor syndrome) that provide direct evidence linking oxidative DNA damage to CRC, and review conflicting evidence on common variants such as hOGG1 Ser326Cys and MUTYH polymorphisms in sporadic CRC risk. They also address the contribution of intestinal dysbiosis to oxidative damage and potential therapeutic strategies targeting DNA repair pathways.

A case-only study of 187 Chinese esophageal squamous cell carcinoma (ESCC) patients receiving definitive radiotherapy found that NEIL1 rs4462560 GC/CC genotypes were associated with significantly lower risk of grade ≥2 acute radiation-induced esophageal toxicity (RIET) (HR=0.421, p=0.017) and grade ≥2 radiation pneumonitis (RP) (HR=0.392, p=0.037) compared with GG genotype, but no association with overall survival. Five other SNPs in FEN1 and hOGG1 genes showed no significant associations.

Candidate gene association study of 67 genetic variants in 27 inflammation and DNA repair genes with hepatitis A virus (HAV) infection susceptibility in 6,779 NHANES III participants (2,619 non-Hispanic whites, 2,095 non-Hispanic blacks, 2,065 Mexican Americans). Among Mexican Americans, ABCB1 rs1045642 T allele was associated with lower HAV seropositivity risk (OR=0.79, p<0.001), while TGFB1 rs1800469 and XRCC1 rs1799782 T alleles were associated with increased risk (OR=1.38 and 1.57, respectively). CAT rs769214 and CYP2E1 rs2031920 showed marginal associations with decreased and increased HAV risk, respectively.

This meta-analysis of 12 case-control studies (4,233 cases, 6,494 controls) evaluated the association between OGG1 Ser326Cys polymorphism (rs1052133) and colorectal cancer risk. No significant associations were found across any genetic model: Cys/Cys vs Ser/Ser (OR=1.19, 95% CI 0.92-1.53), Ser/Cys vs Ser/Ser (OR=1.04, 95% CI 0.95-1.13), or dominant model Ser/Cys+Cys/Cys vs Ser/Ser (OR=1.06, 95% CI 0.98-1.16). Stratified analyses by ethnicity and control source also revealed no increased risk.

Two-stage case-control study in Spanish population examining 76 polymorphisms in 27 oxidative stress-related genes for breast cancer susceptibility. Six SNPs (rs1052133 in OGG1, rs406113 and rs974334 in GPX6, rs2284659 in SOD3, rs4135225 in TXN, rs207454 in XDH) were significantly associated with breast cancer risk. A four-variant interaction (rs406113, rs974334, rs1052133, rs2284659) showed increased risk with OR = 1.75 [95% CI: 1.26-2.44], p-value = 0.0008.

Meta-analysis of 152 case-control studies investigating the OGG1 Ser326Cys polymorphism (rs1052133) and cancer risk. Overall results showed significant associations across multiple genetic models (dominant: OR=1.053, P=0.018; recessive: OR=1.108, P<0.001; homozygote: OR=1.135, P<0.001; additive: OR=1.059, P<0.001). However, subgroup analyses by cancer type, sample size, and source of controls yielded inconsistent results, with only leukemia showing a significant association. The authors concluded that the overall evidence does not reliably support OGG1 Ser326Cys as a risk factor for cancer.

This meta-analysis of 7 case-control studies (1,546 HCC cases, 1,620 controls) in East Asian populations found that the hOGG1 Ser326Cys polymorphism (rs1052133) is a significant risk factor for hepatocellular carcinoma (HCC) in Chinese populations (homozygous model: OR=1.99, 95% CI=1.44-2.75; recessive model: OR=1.42, 95% CI=1.08-1.87), but no significant associations were observed in overall East Asian analysis after excluding studies deviating from Hardy-Weinberg equilibrium.

Case-control study of 1,150 bladder cancer cases and 1,149 controls analyzing 43 SNPs in 12 base excision repair (BER) genes. Significant associations with bladder cancer risk were found for OGG1 rs125701 (OR=0.78, 95% CI 0.63-0.96, decreased risk), PARP1 rs1136410/V762A (OR=1.24, 95% CI 1.02-1.51, increased risk), and POLB rs3136717 (OR=1.30, 95% CI 1.04-1.62, increased risk). Meta-analysis of XRCC1 rs25487 (Q399R) across 7 studies showed no overall association with bladder cancer risk.