rs1056515

This variant is located in the RGS5 gene.

▶

Research that mentions this SNP (1)

▶
Genetic variations in regulator of G‐protein signaling (RGS) confer risk of bladder cancer
AssociationN=1,606Eugene K. Lee et al.(2013)· Cancer

Case-control study of 803 bladder cancer patients and 803 healthy controls examining 95 SNPs in 17 RGS (Regulator of G-Protein Signaling) pathway genes. Rs10759 in RGS4 showed the strongest association with reduced bladder cancer risk (OR 0.77, P<0.001), and cumulative analysis of 5 significant SNPs yielded OR 4.13 (95% CI 2.14-7.98) for high-risk genotype combinations. Eleven and thirteen SNPs were associated with recurrence and progression in non-muscle invasive bladder cancer (NMIBC); rs2344673 in RGS5 was most significant for death in muscle-invasive bladder cancer (MIBC), with median survival of 13.3 months vs 81.9 months.

Traits studied:Bladder cancer death/survivalBladder cancer progressionBladder cancer recurrenceBladder cancer riskMuscle-invasive bladder cancer (MIBC)Non-muscle invasive bladder cancer (NMIBC)
PubMedDOIMetascience Observatory

About RGS5

This locus represents naturally occurring readthrough transcription between the neighboring LOC127814295 (uncharacterized LOC127814295) and RGS5 (regulator of G-protein signaling 5) genes on chromosome 1. Some variants of the readthrough transcript encode novel proteins with unique N-termini. [provided by RefSeq, Nov 2022]

View all RGS5 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…