rs1056892
This is a protein-altering variant in the CBR3 gene.
▶Research that mentions this SNP (1)
▶Validation of variants inSLC28A3andUGT1A6as genetic markers predictive of anthracycline‐induced cardiotoxicity in childrenReviewVisscher H. et al.(2013)· Pediatric Blood & Cancer
A Russian-language review examining molecular and genetic aspects of cardiotoxicity from anticancer chemotherapy. The paper discusses genetic polymorphisms in ABC transporters (ABCC1, ABCC2, ABCB1), nucleotide transporters (SLC28A3), and genes involved in oxidative stress (CYBA, RAC2, NCF4, CBR3) that predispose patients to chemotherapy-induced cardiotoxicity. Key findings include rs8187710 in ABCC2 (p=0.0009), rs4673 in CYBA (p=0.04), and rs13058338 in RAC2 (p=0.02) significantly increasing cardiotoxicity risk, while rs1045642 in ABCB1 and rs7853758 in SLC28A3 show cardioprotective properties.
About CBR3
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]
View all CBR3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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