rs1059394

A case-control study of 1,115 gastric cancer (GCa) cases and 1,172 controls from Eastern China examined whether 42 common genetic variants associated with GCa susceptibility predict patient prognosis. A weighted genetic risk score (GRS) was constructed and tested in 633 GCa cases using Cox proportional hazards regression. The results found no significant association between increasing GRS and risk of death (low vs medium: HR=0.87, P=0.349; high vs medium: HR=0.97, P=0.847), and GRS did not improve prognostic prediction beyond clinical factors alone (C-index 0.78 vs 0.78, P=0.986). Genetic variants associated with gastric cancer susceptibility do not appear to predict worse prognosis in Chinese gastric cancer patients.

A hospital-based case-control study of 543 breast cancer cases and 580 controls found that the TYMS rs16430 0bp variant allele was significantly associated with increased risk of breast cancer in non-Hispanic white women aged ≤55 years (adjusted OR 1.37-1.39, P = 0.009-0.010). The rs16430 variant is located at a microRNA-binding site in the TYMS 3' UTR and influences miR-561 binding, leading to altered TYMS mRNA levels.

This case-control study of 605 glioma patients and 1,300 controls found that TYMS rs1059394 (C>T) TT and CT+TT genotypes were associated with significantly decreased glioma risk (OR=0.71, 95% CI=0.52-0.97, P=0.03 for TT; OR=0.74, 95% CI=0.55-0.99, P=0.04 for CT+TT). In high-grade gliomas, rs2847153 (G>A) GA and GA+AA genotypes were significantly increased compared to GG (OR=2.01, 95% CI=1.39-2.91, P<0.001 for GA; OR=1.78, 95% CI=1.25-2.54, P<0.001 for GA+AA). eQTL analysis suggested these polymorphisms alter TYMS gene expression.