rs1062070

This is a synonymous variant in the RNF5 gene — it does not change the protein's amino acid sequence.

▶

GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

dental caries

Nogawa S et al. “Genome-wide association meta-analysis identifies two novel loci associated with dental caries.” Bmc Oral Health 24(1):1003 (2024)

Allele G

OR 9.61

p 7.0e-22

N 533,348

Meta-analysisLarge GWAS

multi-ancestry

fat pad mass

Harris BHL et al. “New role of fat-free mass in cancer risk linked with genetic predisposition.” Scientific Reports 14(1):7270 (2024)

Allele G

OR 0.03

p 3.0e-17

N 337,196

Large GWAS

European

About RNF5

The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]

View all RNF5 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Loading comments…