rs1064395

This is a downstream gene variant variant in the NCAN gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body mass index

Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)

Allele G

OR 0.02

p 1.0e-17

N 1,122,049

Large GWAS

European

bipolar disorder

Cichon S et al. “Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder.” American Journal of Human Genetics 88(3):372-81 (2011)

Allele A

OR 1.17

p 2.0e-9

N 1,982

Large GWAS

European

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Research that mentions this SNP (1)

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A genome-wide supported psychiatric risk variant inNCANinfluences brain function and cognitive performance in healthy subjects

AssociationN=110Heidelore Raum et al.(2015)· Human Brain Mapping

This fMRI study examined how the NCAN SNP rs1064395 (a genome-wide supported psychiatric risk variant) influences brain function and cognitive performance in 110 healthy individuals. Risk allele (A) carriers showed poorer verbal memory performance (p=0.002 for immediate recall, p=0.002 for delayed recall) and a lack of task-related deactivation in the left middle temporal gyrus/temporal pole during semantic verbal fluency tasks, compared to GG homozygotes. Greater deactivation in this region was significantly associated with better verbal memory performance in GG subjects (r=-0.28, p=0.012).

Traits studied:bipolar disordercognitive performanceschizophreniaverbal fluencyverbal memory

PubMed DOI Metascience Observatory

About NCAN

Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002]