rs1065656

This variant is located in the NUBP2 gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

insulin-like growth factor-binding protein 3 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.10
p 3.0e-83
N 47,745
Large GWAS
European

protein measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele C
OR 0.21
p 1.0e-51
N 10,708
Large GWAS
European

IGFBP-3 measurement

Teumer A et al. “Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.” Aging Cell 15(5):811-24 (2016)
Allele G
OR —
p 9.0e-23
N 18,995
Meta-analysisLarge GWAS
European
Kaplan RC et al. “A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.” Human Molecular Genetics 20(6):1241-51 (2011)
Allele G
OR —
p 1.0e-11
N 10,280
Large GWAS
European

IGF-1 measurement, IGFBP-3 measurement

Teumer A et al. “Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.” Aging Cell 15(5):811-24 (2016)
Allele C
OR —
p 2.0e-21
N 18,995
Meta-analysisLarge GWAS
European

About NUBP2

This gene encodes an adenosine triphosphate (ATP) and metal-binding protein that is required for the assembly of cyotosolic iron-sulfur proteins. The encoded protein functions in a heterotetramer with nucleotide-binding protein 1 (NUBP1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

View all NUBP2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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